Serum Concentrations of Various Hormones Following Exposure to Chemical Weapons Containing Sulfur Mustard

Authors

  • Fereydoun Azizi Faculty of Medicine, Shahid Beheshti University of Medcal Sciences,Tehran,Iran.
  • Hamid Sohrabpour Faculty of Medicine, Shahid Beheshti University of Medcal Sciences,Tehran,Iran.
  • Hossein Elyasi Faculty of Medicine, Shahid Beheshti University of Medcal Sciences,Tehran,Iran.
  • Mahtalaat Nafarabaci Faculty of Medicine, Shahid Beheshti University of Medcal Sciences,Tehran,Iran.
  • Naser Jalali Faculty of Medicine, Shahid Beheshti University of Medcal Sciences,Tehran,Iran.
Abstract:

Serum concentration of FSH, LH, testosterone, prolactin,ACTH,cortisol, TSH, T ,T and resin Tuptake were measured in 146 men who were exposed to vesicants used by Iraqi regime, few days to 4 weeks prior to test'ing, Clinical and laboratory findings had confirmed that mustards had been used. Mean serum concentrations of FSH, LH, TSH and prolactin were not signi­ficantly different from normals. Free Tindex (FTI) was ·subnormal in 6 men, 4 and its mean was somewhat decreased (7 .4 ± 0.8 vs; normal 8. 7 ± 1. 2;P""- 0.05). Free Tindex (FTI) was subnormal in 14 men, and its mean was significantlylower than normal (92±20 vs 130±11; P < 0.001). Serum testosterone concentration was subnormal in 42 men, and its mean was significantly lower than normal (361 ± 254 vs 676 ± 273 ng/dl; P..( 0.001). Serum cortisol, was subnormal in 11 and above normal in 8 men, its mean was not significantly different from normal values. There was an increase in serum ACTH concentration. We conclude that exposure to chemical weapons containing mustards may cause sever alterations in serum concentrations of various hormones. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

SERUM CONCENTRATIONS OF VARIOUS HORMONES FOLLOWING EXPOSURE TO CHEMICAL WEAPONS CONTAINING SULFUR MUSTARD

Serum concentration of FSH, LH, testosterone, prolactin, ACTH, cortisol, TSH, T4, T3 and resin T3 uptake were measured in 146 men who were exposed to vesicants used by the Iraqi regime a few days t04 weeks prior to testing. Clinical and laboratory findings had confirmed the use of mustard gas. Mean serum concentrations of FSH, LH, TSH and prolactin were not significantly different from no...

full text

serum concentrations of various hormones following exposure to chemical weapons containing sulfur mustard

serum concentration of fsh, lh, testosterone, prolactin, acth, cortisol, tsh, t4, t3 and resin t3 uptake were measured in 146 men who were exposed to vesicants used by the iraqi regime a few days t04 weeks prior to testing. clinical and laboratory findings had confirmed the use of mustard gas. mean serum concentrations of fsh, lh, tsh and prolactin were not significantly different from normal v...

full text

Reproductive Function In Men Following Exposure to Chemical Warfare Containing Sulfur Mustard

  SUMMARY In order to investigate acute and chronic effects of exposure to warfare containing mustards in young men, the time course of changes in serum concentrations of total and free testosterone, dehydroepiandrosterone (DS), FSH, LH and prolactin was evaluated in 16 men in the first 3 months and testicular function in 42 men one to three years after injury. Serum total and free testostero...

full text

The Concentration of Thyroid Hormones, Cortisol and ACTH Exposed to Chemical Weapons

  ABSTRACT In order to evaluate time course of changes in serum concentration of thyroid hormones, cortisol and ACTH in patients exposed to chemical weapons containing sulfur mustard, we measured serum concentrations of hormones on the first, third and fifth week following injury in 13 soldiers and compared them to the results obtained from 34 control men. Free T4 and T3 indices were decrease...

full text

Sulfur Mustard Toxicity Following Dermal Exposure

OBJECTIVE Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an important factor in HD skin toxicity. Oxidative stress results when the production of reactive oxygen ...

full text

The Association between Ocular Problems and Serum Testosterone, Prolactin and Thyroglobulin Concentrations in Delayed Phase of Sulfur Mustard Exposure

Background and objective Aside from direct toxic effects, Sulfur Mustard (SM) induced serum hormone abnormalities may aggravate ocular complaints, including Ocular Surface Discomfort (OSD) (burning, itching, and redness), dry eye sensation, photophobia, blurred vision, foreign body sensation, and pain. The aim of the current study was to investigate the possible associ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue 3

pages  97- 101

publication date 1987-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023